JIMMY L. SPEAROW, Ph. D.
Staff Toxicologist
Department of Toxic Substances Control
California Environmental Protection Agency
8800 Cal Center drive
Sacramento, California 95826
Phone (916) 255-6639
also
Department of Civil and Environmental Engineering
Rm 1014 Engineering III
University of California at Davis
Davis, California 95616
Cell Phone (530) 902-2041
Email jlspearow@sbcglobal.net
Web site http://www.reproductivegenetics.org
EDUCATION
B.S. Animal Science 1973. Summa Cum Laude. Texas A&M University, College Station Texas.
Ph.D. Genetics 1980, University of California at Davis.
Physiological Genetics / Biochemistry / Animal Breeding.
Post-Doctorate 1980-1983: University of Michigan, Ann Arbor, MI. Human Genetics and Reproductive Endocrinology
RECENT RESEARCH, TEACHING AND PROFESSIONAL EXPERIENCE
Professional Development Sabbatical Leave: Lawrence Livermore National Laboratory, Human Genome Center, in the laboratory of Dr. Lisa Stubbs. Fall 1998. Molecular Biology, Genomic and Positional cloning methods.
Lecturer and Assistant Research Geneticist / Associate Research Geneticist / 1988 to 2003. Section on Neurobiology, Physiology and Behavior, and Section of Molecular and Cellular Biology, University of California at Davis, Davis CA. Teaching: 1) Genetics; 2) Hormones and Behavior; and, 3) Molecular genetics, reproducitve endocrinology/physiology research methods. Research- see below
Associate Research Geneticist: 2003 to 2006. Department of Environmental Toxicology, University of California, Davis, CA.
Research on:
1) Screening for and characterizing major genetic differences in gonadotropin-induced ovulation rate, and gonadotropin-induced aromatase activity between strains of mice;
2) Mapping and characterizing Quantitative Trait Loci (QTL), i.e. genes, controlling major differences in gonadotropin-induced ovulation rate and aromatase activity using in mouse crosses and Recombinant Inbred strains.
3) Developing reproductive congenic strains of mice differing in gonadotropin-induced ovulation rate and aromatase activity using marker assisted selection and using them to higher resolution map reproductive QTL.
4) Mapping and determining the regulation of soluble epoxide hydrolase
5) Screening for and characterizing major mouse strain differences in susceptibility to the disruption of spermatogenesis and male and female reproductive development by estrogen and Bisphenol A.
6) Determining physiological and transcriptional mechanisms mediating Genetic differences in susceptibility to the disruption of reproductive development by estrogens.
7) Developing Estrogen Receptor action INdicator (ERIN) transgenic mice on both estrogen-sensitive and estrogen-resistant mouse strain backgrounds.
8) Determining effects of mouse sperm cryopreservation methods on genetic stability.
9) Determining effects of environmental tobacco smoke exposure on rat and monkey sperm genetic and oxidative damage endpoints. Sperm toxicological endpoints examined include: a) genetic damage as determined by TUNEL and Benzo[a]pyrene –DNA adduct assays; as well as, b) oxidative damage as determined by lipid peroxidation and protein carbonyl assays.
Staff Research Assistant: 2006 to 2007. Department of Civil and Environmental Engineering, University of California, Davis, CA.
1) Research on Biomarkers for exposure of Striped Bass to Environmental Toxicants.
Staff Toxicologist: 2007 to present. Department of Toxic Substances Control, California Environmental Protection Agency. Sacramento, California.
1) Working to insure that California schools are free from risks of toxic chemicals.
2) Research on Endocrine Disruptors and the Bioavialability of Arsenic and other metals in soil.
SCIENTIFIC INPUT REGARDING NATIONAL PUBLIC POLICY:
National Toxicology Program / Environmental Protection Agency Endocrine Disruptors Low-Dose Peer Review, October 10-12, 2000. Invited to contribute data and participate as an independent scientist in reviewing the scientific evidence related to low-dose effects of endocrine disruptors. Considered the implications of genetic variation in susceptibility to endocrine disruption on the development, validation and interpretation of reproductive and developmental toxicity assays.
Reviewer for the US EPA’s White Paper on “Species/Strain/Stock in Endocrine Disruptor Assays.” At the request of the US Environmental Protection Agency (EPA), I served as the sole external reviewer for the US EPA’s White Paper on “Species/Strain/Stock for Mammalian in vivo Endocrine Disruptor Assays. http://www.epa.gov/scipoly/oscpendo/program/whitepaper.htm
Reviewer’s Presentation on EPA White Paper on Species/Strain/Stock in Endocrine Disruptor Assays. National Advisory Council for Environmental Policy and Technology (NACEPT) Endocrine Disruptor Methods Validation Subcommittee (EDMVS) Plenary Meeting. August 18-20, 2003. Golden, Colorado.
Author, Reviewer’s Appendix to the White Paper on Species/Strain/Stock in Endocrine Disruptor Assays. Published by US EPA. March 2005. http://www.epa.gov/scipoly/oscpendo/program/whitepaper.htm
MEMBERSHIP IN PROFESSIONAL SOCIETIES:
American Association for the Advancement of Science (AAAS), Member
Society for the Study of Reproduction (SSR), Member
Complex Trait Consortium (CTC), Member
Physicians for Social Responsibility (PSR), Speaker, and Member of the Executive Board, Sacramento Chapter
Union of Concerned Scientists, Member
Collaborative on Health and the Environment (CHE)
Northern California Regional Chapter of the Society of Environmental Toxicology and Chemistry, Member
International Mammalian Genome Society, (Membership not current)
SELECTED PUBLICATIONS:
Jiang I. Wu, M. A. Centilli, Gabriela Vasquez, Susan Young, Jonathan Scolnick, Larissa A. Durfee, Jimmy L. Spearow, Staci D. Schwantz, Gabriela Rennebeck, and Karen Artzt. Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. Genetics, Vol. 177, 1151-1161, October 2007. http://www.genetics.org/cgi/content/full/177/2/1151
Spearow, Jimmy L. 2005. Reviewer’s Appendix to the White Paper on Species/Stock/Strain in Endocrine Disruptor Assays. pp 1-91. http://www.epa.gov/scipoly/oscpendo/program/whitepaper.htm
Clemons, Karl V., Spearow, Jimmy L., Parmar, Rachana, Espiritu, Marife, and Stevens, David A. 2004. Genetic Susceptibility of mice to Candidia albicans Vaginitis Correlates with Host Estrogen Sensitivity. Infection and Immunity 72: 4878-4880.
Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpaa MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F; Complex Trait Consortium. (2004). "The Collaborative Cross, a community resource for the genetic analysis of complex traits." Nat Genet 36(11): 1133-7.
Spearow, Jimmy L., O'Henley, Peter, Doemeny, Paul, Sera, Robyn, Leffler, Rachel, Sofos, Taki, and Barkley, Marylynn. 2001. Genetic variation in physiological sensitivity to estrogen in mice. Acta Pathologica, Microbiologica et Immunologica Scandinavica 109: 356-364.
Spearow, Jimmy L., and Barkley, Marylynn. Reassessment of models used to test xenobiotics for oestrogenic potency is overdue. 2001. Human Reproduction. 16:, No. 5, 1027-1029.
Spearow, Jimmy L., Doemeny, Paul, Sera, Robyn, Leffler, Rachel and Barkley, Marylynn. 1999. Genetic Variation in Susceptibility to Endocrine Disruption by Estrogen in Mice. Science 285: 20th August, 1259-1261.
Tzu-Huey Li, Jimmy Spearow, Carol M. Rubin, Carl W. Schmid. 1999. Physiological stresses increase mouse short interspersed element (SINE) RNA expression in vivo. Gene 239: 367-372.
Spearow, Jimmy L., and Barkley, Marylynn. 1999. Genetic Control of Hormone-Induced Ovulation Rate in mice. Biology of Reproduction 61: 851-856.
Spearow, Jimmy L. , Nutson, Peter A., Mailliard, William S., Porter, Mark, and Marylynn Barkley. 1999. Mapping Genes That Control Hormone-Induced Ovulation Rate in Mice. Biology of Reproduction 61: 857-872.
Jimmy L. Spearow. Regulation of Ovulation Rate. In "Polycystic Ovary Syndrome". Ed R. Jeffery Chang. Publisher Springer-Verlag. NY, NY Inc. 1996. pp 1-20.
Anthony Parker, Franck Pinot, David F. Grant, Jimmy Spearow, and Bruce D. Hammock. 1996. Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones. Biochemical Pharmacology 51:677-685.
Wong, Lawrence, Spearow, Jimmy L., Castracane, V. Daniel, and Barkley, Marylynn. 1995. Genetic variation in plasma androgens and ovarian aromatase activity during mouse pregnancy. Proceedings of the Society for Experimental Biology and Medicine 208:277-282.
Spearow, J.L. 1995. P450 (Cytochrome) oxidoreductase (Por) maps to mouse Chromosome 5, not Chromosome 6. Mammalian Genome. 6 (8):558-559.
Pinot, Franck, Grant, David F., Spearow, Jimmy L., Parker, Anthony G., and Hammock, Bruce D. 1995. Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice. Biochemical Pharmacology 50:501-508.
Grant, David F., Spearow, Jimmy L., Storms, David H., Edelhoff, Susanne, Adler, David, A., Disteche, Christine M.., Taylor, Benjamin A., and Bruce D. Hammock. 1994. Chromosomal mapping and expression levels of a mouse soluble epoxide hydrolase gene. Pharmocogenetics. 4:64-72.
Spearow, J.L., R.P. Erickson, T.I. Edwards and L. Herbon. 1991. The effect of H-2 region and genetic background on hormone-induced ovulation rate, puberty and follicular number in mice. Genetical Research 57:41-49.
Bradford, G.E., Spearow J.L., and J.P Hanrahan. 1991. Genetic Variation and Improvement in Reproduction. In "Reproduction in Domestic Animals." 4th Edition Ed. Perry Cupps. Academic Press. New York. pp. 605-636.
Spearow, J. L. 1988a. Major genes control hormone-induced ovulation rate in mice. Journal of Reproduction and Fertility. 82:787-797.
Spearow, J. L. 1988b. Characterization of genetic differences in hormone-induced ovulation rate in mice. Journal of Reproduction and Fertility. 82:799-806.
Spearow, J. L. and B. Trost. 1987. Development of a sensitive Enzyme-Linked Immunosorbent Assay for Cattle, Sheep, Rat and Mouse Luteinizing hormone. Biology of Reproduction 37:595-605.
Spearow, J. L. 1986. Changes in the kinetics of follicular growth in response to selection for large litter size in mice. Biology of Reproduction 35:1175-1186.
Spearow, Jimmy L. 1985. The mechanism of action of genes controlling reproduction. In: Genetics of Reproduction in Sheep. (R. B. Land and D. W. Robinson, Ed.) Ch. 22, pp. 203-215.
Spearow, J. L. and G. E. Bradford. 1983. Genetic variation in spontaneous ovulation rate and LH receptor induction in mice. J. Reprod. Fertil. 69:529-537.
Spearow, Jimmy L. 1980. The physiological basis of genetic differences in the ovulation rate of mice. Ph.D. Dissertation, University of California, Davis, California. Dissertation Abstract #8027089.
19 INVITED TALKS in last 6 years
49 ABSTRACTS